Schweinfurt has two train stations but neither is a main hub — the Hauptbahnhof (main station) is south of the city centre and requires a short bus connection. Trains run from Würzburg (about 40 minutes) and from Bamberg via Haßfurt. Change at Würzburg for connections from Frankfurt or Munich.
By car, Schweinfurt is on the A70 autobahn and straightforward to reach from both directions. Parking in the town centre is available in several garages near the market square. The town is small enough that a car is not necessary once you've arrived.