Loano sits on the main Genoa–Ventimiglia railway line, with regular services from Genoa (around 1 hour) and Savona (30 minutes). The station is a short walk from the beach. By car, the A10 motorway has an exit at Borghetto Santo Spirito, about 4 km east of the town centre.
The nearest airports are Genoa (Cristoforo Colombo) and Nice Côte d'Azur, both roughly 90 minutes by road. From Nice, the drive along the coast on the A8 and A10 is particularly scenic.