A large Gothic church near the top of the old town, San Domenico was begun in 1275 and retains much of its original structure. The interior is austere — bare brick, a single nave, plain clerestory windows — and the lack of decorative clutter makes the art it contains easier to see clearly.
The Cimabue crucifix hangs above the main altar: a large painted cross in the Byzantine tradition, but with a naturalism in the figure of Christ that marks the beginning of a transition. Alongside the Cimabue are frescoes from various periods (13th–15th century) and a Spinello Aretino altarpiece. The church is free and uncrowded — a quieter alternative to the Basilica di San Francesco for those interested in medieval painting.