The Casa-Museo de Cristóbal Colón sits on the site of the house where Christopher Columbus is generally accepted to have died in 1506. The original building was lost long ago; the current museum, opened in 1968 and expanded in 2006, includes a reconstruction of the house alongside modern exhibition halls.
Inside, the displays cover the four voyages, the pre-Columbian civilisations Columbus encountered, navigational instruments, replicas of the famous letters, and the complicated afterlife of the Columbus story. It is a thorough rather than scintillating museum — worth a visit if you have a half day to spare, especially in combination with the National Museum of Sculpture.