The Río San Juan is the lake's only outlet, draining 200 kilometres east to the Caribbean. For three centuries the river was one of the most strategic waterways in the Americas: ships could come up the river, cross the lake and reach within twenty kilometres of the Pacific, making Nicaragua a natural place for the inter-oceanic canal that was eventually built across Panama instead.
The river is now mostly the preserve of boats, fishermen and the Indio-Maíz biological reserve on its southern bank. From San Carlos at the river's mouth on the lake you can ride a public lancha downstream to El Castillo — a sleepy village dominated by a colonial-era fortress — and continue all the way to the Caribbean if you have the time and the patience. The trip takes you through some of the best-preserved rainforest in Central America.