Fresno is the largest city between Los Angeles and the Bay Area, and its airport reflects that.
Fresno Yosemite International Airport (FAT) is served by a range of carriers with direct flights to Dallas, Denver, Las Vegas, Los Angeles, Portland, Seattle, and other destinations. The airport is about 10 minutes east of downtown. For details, see flyfresno.org.
By car, Fresno sits on Highway 99, the main north-south route through the Central Valley. Highway 41 heads north to Yosemite, and Highway 180 runs east into Kings Canyon.