Tallahassee Regional Airport (TLH) is small but well-connected, with direct flights to Atlanta, Charlotte, Dallas, and a handful of other hubs. American, Delta, and United all serve it. The airport is about 10 minutes from downtown.
By car, I-10 is the main corridor — Jacksonville is about 2.5 hours east, Pensacola about 3 hours west. Atlanta is 4.5 hours north on US 319 through Valdosta.
Greyhound operates a bus station in Tallahassee with connections to Jacksonville, Atlanta, and Pensacola, but schedules are infrequent. Amtrak does not serve Tallahassee.