Plains is on US 280 in southwest Georgia, about 10 miles west of Americus and 140 miles south of Atlanta — roughly 2.5 hours by car. The nearest airports are Atlanta (ATL) and Tallahassee, Florida (TLH), each about 2.5 hours away. There is no rail or commercial bus service into Plains; the railway that gave the town its early life now carries only freight.
The most common approach is by rental car from Atlanta, often combined with an overnight stop in Americus and a visit to Andersonville the same day. Parking in Plains is free and easy.