Jamestown sits in the far southwestern corner of New York State, off Interstate 86 (the Southern Tier Expressway). The closest large airports are Buffalo Niagara International (about 110 km / 70 miles north, around 90 minutes by car) and Pittsburgh International (about 240 km / 150 miles southwest, two and a half hours). Erie, Pennsylvania, is about an hour west.
Jamestown has a small regional airport (JHW) with a single daily United Express service to Washington Dulles, useful mainly for business travellers. Most visitors drive in. There is no passenger rail or scheduled intercity bus into Jamestown proper.