Henryetta is on US Highway 75, about 55 miles south of Tulsa and 25 miles north of McAlester. It is an easy stop on the drive between Tulsa and southeastern Oklahoma. The town sits just off the Indian Nation Turnpike interchange, which makes it a convenient fuel and food stop for travellers heading south from Tulsa toward the Ouachita Mountains.
There is no commercial air service or intercity bus. The nearest airport with scheduled flights is Tulsa International Airport (TUL), roughly an hour's drive north. A car is essential for visiting Henryetta.