Florence sits at the intersection of I-95 and I-20 in the Pee Dee region of South Carolina, roughly halfway between New York and Miami. Most visitors encounter it as a stop on the interstate, but there is enough here to make it more than a fuel break.
The downtown area has a small but pleasant historic district centred on the Florence County Museum, which covers local history from the Civil War through the railroad era. Florence's most sobering site is the Florence Stockade, a Confederate prisoner-of-war camp that held up to 18,000 Union soldiers in 1864–65; over 2,800 died here. The Florence National Cemetery on the south side of town marks the site. For those interested in Cold War oddities, the Mars Bluff Crater — where the US Air Force accidentally dropped a nuclear bomb on a residential neighbourhood in 1958 — is about 12 km east.
Florence is a practical overnight stop for anyone heading to Myrtle Beach, about 90 minutes east, or Charleston, about 2.5 hours south.