Weston sits beside I-79 in north-central West Virginia, about 100 miles south of Morgantown and 100 miles northeast of Charleston. A car is the practical way to visit; the town works well as a stop between the Ohio Valley, Morgantown, and the mountain counties farther east.
The nearest commercial airport is North Central West Virginia Airport near Clarksburg, but most travelers will arrive by road. Downtown, the asylum, and the glass museum are close together, while Stonewall Jackson Lake is a short drive south.