Long-distance buses run several times daily up the Quebrada from San Salvador de Jujuy (about 3 hours) and from Salta (5–6 hours including the Jujuy connection). The Humahuaca bus terminal is a short walk from the plaza.
There is no airport in town. The closest is Jujuy (Horacio Guzmán International), with daily flights from Buenos Aires; from there continue by bus or rented car. Some travellers come down from Bolivia via the border at La Quiaca, then south by bus — a slower but interesting route.