Misool is the southernmost of Raja Ampat's four main islands and arguably the most diverse. The reefs here have benefited from an effective community-run marine protected area, and the diving is exceptional: manta rays cleaning at stations on the outer reef, reef sharks in the channels, and a density of soft coral that makes even experienced divers stop and stare. The landscape above water is as dramatic as Wayag, with karst formations emerging from forested slopes above mangrove-fringed bays.
Misool is about 6–8 hours by boat from Waisai, which makes it primarily a liveaboard destination. A handful of small eco-resorts have been built on the island, operating on conservation principles and employing local Misool communities as guides and staff. Getting here independently is possible but slow.