San Sisto is a Benedictine church just north of the city centre, rebuilt in the early 16th century in a Mannerist style by Alessio Tramello. Its main claim to fame is that it was the original home of Raphael's Sistine Madonna — one of the most famous paintings in the world, now in Dresden — which hung above the high altar from about 1512 to 1754. The copy that replaced it is still in the church.
Even without the Raphael, San Sisto is worth visiting. The facade is an unusual design — three-bay Mannerist composition with pilasters and round-headed niches — and the interior has a long barrel-vaulted nave with good Renaissance stucco decoration. The choir behind the altar is inlaid with intarsia woodwork of exceptional quality. The church is on the north side of the city, about 15 minutes' walk from the Piazza dei Cavalli.