By marshrutka is the standard way in. Minibuses from Chisinau's North Bus Station (Autogara Nord) run every 15–30 minutes during the day, take about 60 to 80 minutes depending on traffic and stops, and cost a few dozen lei. They drop at Orhei's own small bus station near the centre.
By car, the M2 from Chisinau is a reasonable two-lane road taking about an hour. Parking in central Orhei is easy and free.
There is no useful rail service to Orhei.