Domburg is about 15 kilometres west of Middelburg, the capital of Zeeland province. From Middelburg there are regular buses (line 53) that take around 25 minutes. Middelburg is reached by train from Rotterdam or Amsterdam — the Zeeland Bridge and the Delta Works infrastructure mean Walcheren is well connected to the mainland.
By car, Domburg is just over two hours from Amsterdam. In summer, parking in the village fills quickly — it is worth arriving early or using the parking area at the edge of town and walking in.