Monnickendam is easily reached from Amsterdam by bus — routes 110 and 111 depart from Amsterdam Centraal and take around 22 minutes. Buses run frequently throughout the day, making it straightforward as a half-day or day trip.
By car from Amsterdam, follow the A10 ring road east, then take the S116 north through Durgerdam toward Waterland. The drive is around 20 minutes outside rush hour. Parking in the town centre is limited but manageable outside summer weekends.