San Vito is genuinely remote — it takes effort to get here, which is part of why so few tourists come.
By bus is the most common option for travellers without a car. The journey from San José takes around seven hours. There are two main routes: via San Isidro de El General and then south through the mountains, or via Ciudad Neily (near the Panamanian border) and then up into the highlands. Buses depart from the Tracopa terminal in San José. Services run daily but are not frequent — check current schedules before you travel. The road from San Isidro is spectacular, crossing the Cerro de la Muerte ridge with views over both coasts on a clear day.
By car gives far more flexibility and is strongly recommended if you plan to visit Parque Internacional La Amistad or spend time at the Wilson Gardens outside its shuttle schedule. From San José, take the Pan-American Highway south to San Isidro, then continue south on Route 2 toward Paso Canoas; San Vito is accessed via a signed turnoff east of Ciudad Neily. The road climbs steeply from the valley floor and is in reasonable condition, though it rewards careful driving. Alternatively, if you're crossing from Panama at Paso Canoas, San Vito is around an hour north by road.
There are no scheduled flights to or from San Vito. The nearest domestic airport with regular service is in Golfito or Palmar Sur, both of which still require a long drive to reach the town.