Getting to Buffalo is an easy task from a number of major airport hubs.
The major airport hubs serviced include:
JFK - New York (Kennedy) ---Jet Blue
LGA - New York (LaGuardia) ---US Airways
ORD - Chicago (O'Hare) ---United Airlines and American Eagle (American Airlines)
EWR - Newark (Liberty) --- US Airways
IAD - Washington (Dulles) --- Independence Air
DCA - Washington (National) --- US Airways
PHX - Phoenix (Sky Harbor International) --- Southwest
BWI - Baltimore (Baltimore Washington International) --- US Airways, Southwest Airlines
MDW Chicago (Midway) --- Southwest Airlines
LAS Las Vegas (McCarran) --- Southwest Airlines
In addition, Amtrak offers a few trains per day from New York Penn Station and a once-a-day trip from Chicago. Also there is service, once daily from Toronto.