Oklahoma is car country. The interstate system connects the major cities well, and driving is by far the most practical way to get around the state. Traffic is light compared to most American states, and gas is cheap.
By car is the only realistic option for seeing the state properly. I-44 (the Turner Turnpike) connects Oklahoma City and Tulsa. I-35 runs north-south through the center of the state. I-40 crosses east-west through Oklahoma City. Rental cars are available at both major airports.
Route 66 is the classic way to see Oklahoma. With 48 towns and cities along the Mother Road, you can drive the full stretch from Miami in the northeast to Texola on the Texas border. The principal cities from northeast to southwest are Miami, Claremore, Tulsa, Sapulpa, Chandler, Edmond, El Reno, and Elk City.
Public transit is limited. Oklahoma City and Tulsa have basic bus systems, but neither city has rail transit. Greyhound and Jefferson Lines serve the major cities. Amtrak's Heartland Flyer runs daily between Oklahoma City and Fort Worth, Texas.