Lititz has no train or major bus service of its own. The realistic options are by car or via Lancaster, 14 km south.
By car: Lititz sits just off Route 501, about 90 minutes west of Philadelphia (via the Pennsylvania Turnpike) and 90 minutes east of Harrisburg. The drive from Lancaster city is around 25 minutes.
By train: Amtrak's Keystone Service connects Lancaster (the city) with Philadelphia, Harrisburg, and onward to New York and Washington. From Lancaster station, take a taxi or rideshare for the final leg to Lititz.
By air: Harrisburg International Airport (MDT) is the closest major airport, about 60 km west. Philadelphia (PHL) is 110 km east and has wider international connections.