Almelo has its own railway station with direct services to Hengelo and Enschede. From Amsterdam, the most practical route is via Utrecht or Deventer; expect a journey of around 2 hours. The station is a 10-minute walk from the town centre.
By car, Almelo sits just off the A35 motorway that connects Hengelo to Almelo and continues east towards the German border at Bad Bentheim.