Yakutsk is one of the most remote cities of its size on the planet. There is no continuous road link to the rest of Russia, and the railway only reached Nizhny Bestyakh on the opposite bank of the Lena in 2019. For most travellers, flying is the only realistic option.
By air: Platon Oyunsky Yakutsk International Airport sits a few kilometres north of the city. Direct flights connect to Moscow (about seven hours), Novosibirsk, Khabarovsk, Vladivostok, and Irkutsk. There are also seasonal links to Beijing and Seoul. The airport handles a lot of small regional traffic to villages across Sakha that have no roads at all.
By road: The Kolyma Highway (the "Road of Bones") connects Yakutsk overland to Magadan, a journey of around 2,000 km. It is rough, mostly unpaved, and only really passable in winter when the rivers freeze. The Lena Highway runs south to Skovorodino on the Trans-Siberian, but for half the year it is interrupted by the Lena ferry crossing.
By rail: The Amur-Yakutsk Mainline now terminates at Nizhny Bestyakh, across the river from Yakutsk. There is no permanent bridge, so you transfer to a ferry in summer or drive across the ice in winter. The journey from Moscow takes around a week.