The Museo de Antropología e Historia occupies a handsome building near the central park and offers the most comprehensive survey of pre-Columbian Honduras outside Tegucigalpa. The exhibits cover the indigenous cultures of the Sula Valley and the north coast — particularly the Lenca people, who developed sophisticated ceramics and agricultural systems long before European contact.
The colonial and modern history sections give context to how San Pedro Sula developed from a colonial trading post into Honduras's industrial capital. If you have a day to fill in the city, this is the most rewarding indoor stop — well-organised, air-conditioned, and covering material you will not find easily elsewhere. Allow 90 minutes.