The Museo de Sonora occupies the 19th-century state penitentiary in the heart of the city, and it is far and away the best museum in Hermosillo — and arguably the best in the entire state. The collection covers Sonoran history from pre-Columbian times through the present, with strong sections on the Yaqui, Seri, Pima, and Tohono O'odham peoples.
The building itself is the attraction. The thick-walled cells, the vaulted corridors, and the central courtyard create an environment unlike any conventional museum. Exhibits are well presented in Spanish with some English signage. Allow at least two hours. The museum is located in Jesús García Avenue in the historic centre; admission is inexpensive.