Museo Zacatecano covers the city and state's history, with exhibits on local figures, regional crafts, and Zacatecas culture. Its Huichol collection is the highlight, with beadwork, textiles, and ceremonial objects from communities in the mountains between Zacatecas and Nayarit.
The museum is close to Santo Domingo and the cathedral, so it works well as part of a walk through the historic center.