The Cathedral of Trujillo faces the Plaza de Armas and took well over a century to complete, begun in 1647 and only consecrated in 1771. The façade combines Baroque European forms with decorative elements drawn from indigenous tradition — an approach called Mestizo or Andean Baroque that is characteristic of colonial-era churches in northern Peru.
The interior is notable for its gilded altarpieces and several paintings from the colonial period. A small attached museum houses religious art, silver work, and documents from the cathedral's history. Entry to the cathedral is free outside of Mass times.