Busselton is on the Bussell Highway, about 220 km (a two-and-a-half-hour drive) south of Perth. The town does not have a passenger rail line; Transwa runs daily coaches from Perth via Bunbury, taking around three and a half hours.
The Busselton Margaret River Airport (BQB), 10 km east of the centre near Yalyalup, takes scheduled flights from Melbourne in peak summer and a handful of regional routes. Most visitors fly into Perth (PER) and drive down.