Termoli sits on the main Adriatic coastal railway, with direct intercity trains from Bologna, Ancona, Pescara, Bari, and Lecce. The journey from Rome requires a change at Pescara or Foggia and takes around four and a half hours.
By car, the A14 motorway runs just inland — exit at Termoli and you are five minutes from the seafront. The town is also the port for ferries to the Tremiti Islands (Tirrenia and Navigazione Libera del Golfo run services from June to September, more limited in winter).