Magione's position near the Umbria–Tuscany border and at the centre of a network of lake towns makes it an effective base for day trips.
Perugia (20 km east) is the obvious first choice — Umbria's regional capital has a well-preserved medieval centre, the Galleria Nazionale dell'Umbria (one of the best collections of Umbrian painting in existence), the Fontana Maggiore, and the underground Roman ruins of the Rocca Paolina. It is easily reached by car in 25 minutes or by the Ferrovia Centrale Umbra in the same time.
Castiglione del Lago (20 km west) sits on a promontory jutting into Lake Trasimeno and has one of the most dramatically sited castles in Umbria. The Palazzo della Corgna and the Rocca Medievale are connected by an elevated walkway along the town walls. The views from the promontory across the lake are excellent.
Cortona (35 km west, in Tuscany) is a steep hill town with a Museo Diocesano containing two exceptional Fra Angelico panels. It is more visited than most Umbrian destinations but retains a genuine character. The drive from Magione through the Val di Chiana is pleasant.
Città della Pieve (30 km south-west) is the birthplace of Perugino, the painter who taught Raphael. The town itself is built almost entirely in brick — unusual for this part of Umbria — and has several Perugino frescoes still in situ in local churches.
Assisi (35 km east) needs no introduction. The Basilica di San Francesco with its Giotto frescoes is one of the great medieval buildings of Italy. It is crowded in high summer, but a weekday visit out of peak season remains genuinely moving. The drive from Magione across the Umbrian plain with Monte Subasio rising above Assisi is one of the better approaches.