Wageningen has no train station. The nearest stations are Ede-Wageningen (about 9 km north) and Arnhem Centraal (30 km east), both on the main Amsterdam–Arnhem–Germany line. From Ede-Wageningen, bus line 88 runs directly into Wageningen town centre in around 20 minutes. From Arnhem, several bus lines connect to Wageningen.
By car, Wageningen is easily reached from the A12 or A15 motorways. Amsterdam is about 85 km and 80 minutes away; Arnhem is 30 km. Parking in the town centre is limited but manageable outside peak hours.
Cycling is a genuine option from Ede-Wageningen station, and the route is flat and well-signed.