Ste. Genevieve is Missouri's oldest community, founded by French settlers around 1735 on the banks of the Mississippi River. It has one of the most important collections of French colonial architecture in North America — the distinctive vertical-log (poteaux-sur-solle) construction technique used here is rarely found elsewhere in the United States. The town became a National Historical Park in 2020, recognising its significance.
Several key buildings are open to visitors. The Louis Bolduc House (c. 1792) is a National Historic Landmark and the finest surviving French colonial structure on the continent. The Beauvais-Amoureux House is one of only five surviving poteaux-en-terre buildings — vertical logs buried directly in the ground — left in the country. The Felix Vallé House (1818) represents the town's later fur-trade era.
Ste. Genevieve sits on the Great River Road about an hour south of St. Louis. The town is compact and walkable, and the Memorial Cemetery — the oldest in Missouri — is worth a short detour for its French-inscribed headstones. South of town, the Cave Vineyard offers wine tastings inside an actual limestone cave.