Charleston sits at the junction of three major interstates — I-64, I-77, and I-79 — making it an easy stop if you're driving through West Virginia. The Yeager Airport (CRW) handles regional connections to major hubs. Amtrak's Cardinal line runs three times a week in each direction between New York/Washington DC and Chicago via Cincinnati, stopping at the Charleston Amtrak station on the north side of the river.