Termoli's Museum of Contemporary Art, often branded MACTE, gives the seaside town a cultural stop beyond the old borgo and cathedral. Its collection is tied to the Premio Termoli, an art prize that helped bring modern and contemporary Italian work to Molise. The result is compact, regional, and more interesting than its size suggests.
It is a good rainy-day or hot-afternoon stop, especially if you like seeing how smaller Italian cities build cultural life outside the big museum circuits. Check current exhibitions before going, since the temporary programme can shape the visit. Combine it with a walk through the old town and the harbor.