The Museo Archeologico Regionale Paolo Orsi is the finest archaeological museum in Sicily and one of the best in Italy, housing finds from ancient Syracuse and the broader Greek and prehistoric presence across Sicily. The collection ranges from the Neolithic through the Greek and Roman periods, with particular strength in Greek sculpture, terracotta votive objects, and coins.
The museum is housed in a modern building in the gardens of the Villa Landolina, a ten-minute walk from Ortigia. Allow at least two hours, more if you have serious interest in the ancient world. The Landolina Venus — a 2nd-century BC Greek marble torso found in a Syracuse garden in 1804 — is in room four and is worth the price of admission on its own.