The Czartoryski Museum holds one of Poland's greatest private art collections, assembled by Princess Izabela Czartoryska in the early 19th century as a deliberate act of cultural preservation during the period when Poland had been partitioned and ceased to exist as an independent state. The museum reopened after an extensive restoration in 2019 with new display spaces in the renovated arsenal buildings adjacent to the original palace.
The collection's supreme prize is Leonardo da Vinci's Lady with an Ermine (1490), one of only four paintings by Leonardo in existence and widely considered one of the finest portrait paintings ever made. The subject is Cecilia Gallerani, the young mistress of Ludovico Sforza, Duke of Milan. The painting is displayed in a dedicated room under ideal lighting conditions. Beyond the Leonardo, the collection includes ancient Greek and Roman antiquities, medieval art, European decorative arts, and paintings by Rembrandt, Giorgione, and other European masters. The museum is on the northern edge of the Old Town, a short walk from the Main Square.