The Cathedral of San Juan Bautista, dedicated in 1521, is the second oldest cathedral in the Americas. The original wooden structure burned and the current Gothic-influenced building is mostly a sixteenth-century reconstruction, with later baroque additions; the ribbed vaults of the side chapels are the parts most worth looking up at.
Inside, the marble tomb of Ponce de León is the headline attraction, and there is a glass case displaying the embalmed body of Saint Pío, a Roman martyr whose relics were sent here in 1862. The cathedral square outside is a fine place to sit with a coffee; the building opposite is the Hotel El Convento, a former Carmelite convent that became one of the first heritage hotels in the Americas.