The Universidad Mayor Real y Pontificia de San Francisco Xavier de Chuquisaca was founded by the Jesuits in 1624, making it one of the oldest universities still operating in the Americas — older than Harvard. The original colonial buildings around the small Plaza San Francisco Xavier on Calle Nicolás Ortiz are open to visitors during the day. The rectory courtyard with its slim white columns is photogenic, and the small Museo Universitario inside displays portraits of distinguished alumni, antique scientific instruments, and an original first edition of the constitution of the Audiencia de Charcas.
The university remains a strong cultural presence in the city today, with around 40,000 students keeping the cafes, bookshops, and bars full year-round. Its law faculty has educated several Latin American presidents; its medical school is one of the most respected in the country. If you visit during semester, you will hear lectures in progress through open windows — a strangely beautiful soundtrack to a wander through the old quarter.