The Pamir Highway is the primary reason many travelers come to Dushanbe: the city is the starting point for one of the great overland routes in the world. From Dushanbe, the M41 climbs southeast through the Hissar and Darvaz ranges, passes through Qurghonteppa and Kulob, then enters the dramatic Panj River gorge that forms the Afghan border.
The road continues through Khorog (capital of Gorno-Badakhshan) and on to the high plateau of the eastern Pamirs — an otherworldly landscape of flat, treeless plains at 4,000 meters, bracketed by peaks exceeding 6,000 meters. Most travelers hire a driver in Dushanbe for the journey; the drive from Dushanbe to Osh takes 4–6 days with stops. The route requires a Gorno-Badakhshan permit, available in Dushanbe.