Via San Vincenzo, running south from the Brignole station area, is Genoa's finest food street: a concentrated row of focaccerias, pastry shops, cheesemakers, and delicatessens. Luigi is among the oldest and best of the focaccerie, selling focaccia genovese (thin, crispy, oil-soaked, dimpled) and focaccia col formaggio (the soft, cheese-filled variant from nearby Recco) by the slice from the morning onwards.
The focaccia here is eaten standing at the counter or on the pavement outside. It costs almost nothing, it is excellent, and it is made continuously throughout the day so you will almost always get it warm. Arrive before 9am for the first batch.