Matucana 100 is an independent cultural centre in a converted industrial building near Quinta Normal, running theatre performances, contemporary dance, music, and visual art exhibitions. It is one of the most artistically serious venues in the city — the kind of place that hosts experimental theatre from South America and Europe alongside Chilean work — and its programming is reliably interesting.
The venue is named for its address (Matucana 100, in Estación Central commune) and has several performance spaces, an outdoor theatre, and a café. It tends to be less crowded than the more central venues and has a genuinely alternative atmosphere. Check the website for current programming; prices are typically very reasonable. Close to the Quinta Normal metro station.