The Galleria Regionale, in the 15th-century Catalan Gothic Palazzo Abatellis in the Kalsa, is Sicily's best art museum. The collection covers Sicilian and southern Italian painting and sculpture from the 12th to the 17th century — strong on the indigenous Sicilian school but with major works by visitors and incomers like Antonello da Messina.
The Triumph of Death dominates the upper floor and is worth as much time as you can give it; the iconography is unusual and the painting is far better than reproductions suggest. Antonello's Virgin Annunciate is in a small dedicated room nearby. Closed Mondays.