MUSA, the University of Guadalajara's Museum of the Arts, is a compact art museum focused on temporary exhibitions and local cultural programming. Its strongest reason to visit is the historic university auditorium, where murals by José Clemente Orozco give the building national significance.
The museum works well as a short stop while exploring the blocks around Templo Expiatorio. Check the current exhibitions before going, but even between major shows the Orozco setting makes it worth considering.