MeetFactory is an independent contemporary art centre in Smíchov, with gallery shows, concerts, theatre, and artist residencies under one roof. It is less polished than Prague's big museums, but that is part of the appeal: the programming feels current and local.
Check the schedule before going, since the best reason to visit is often a specific exhibition or evening event. It is a good stop for travellers who want Prague's living art scene rather than another Baroque facade.