The Staropramen Brewery Visitor Center introduces the Smichov brewery that has been making one of Prague's best-known beers since 1869. The visit is more polished brand experience than old working brewery tour, but it gives useful context for the city's brewing culture outside the historic pub circuit.
It is most worthwhile if you are already exploring Smichov or want a beer-focused stop away from the Old Town. The complex also has a restaurant, so it can work as an easy lunch break with a short tour attached.